N1-Methylpseudo-UTP CAS 1428903-59-6

• Identification
• Properties
• Safety Data
• Specifications & Other Information
• Links

Identification

CAS Number

1428903-59-6

Name

N1-Methylpseudo-UTP

Synonyms

1-Methylpseudouridine-5′-Triphosphate;
N1-Methylpseudo-UTP;
2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-1-methyl-;
1-Methylpseudo-UTP

SMILES

CN1C=C(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O

StdInChI

InChI=1S/C10H17N2O15P3/c1-12-2-4(9(15)11-10(12)16)8-7(14)6(13)5(25-8)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,5-8,13-14H,3H2,1H3,(H,20,21)(H,22,23)(H,11,15,16)(H2,17,18,19)

StdInChIKey

OLRONOIBERDKRE-UHFFFAOYSA-N

Molecular Formula

C₁₀H₁₇N₂O₁₅P₃

Molecular Weight

498.171

Properties

Appearance

Clear colourless solution

Safety Data

RIDADR 

NONH for all modes of transport

Specifications and Other Information of Our N1-Methylpseudo-UTP CAS 1428903-59-6

Identification Methods

HNMR, HPLC

Purity

95%min

Concentration

100 mM – 110 mM

pH

7.5 ±0.5

Spectroscopic Properties

λ_max 271 nm, ε 8.9 L mmol^-1 cm^-1 (Tris-HCl pH 7.5)

Shelf Life

12 months

Storage

Storage at -20°C, Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Known Application

N1-MethylpseudoUridine-5′-Triphosphate is a modified NTP for incorporation into messenger RNAs (mRNA) using T7 RNA Polymerase. Incorporation of N1-methylpseudouridine can reduce the immunogenicity of the resulting mRNA.

Links

This product is developed by our R&D company Watson International Ltd (https://www.watson-int.com/).