Structure of BTB-1 CAS 86030-08-2

BTB-1 CAS 86030-08-2

Identification

CAS Number

86030-08-2

Name

BTB-1

Synonyms

4-Chlor-2-nitro-1-(phenylsulfonyl)benzol [German] [ACD/IUPAC Name]
4-Chloro-2-nitro-1-(phenylsulfonyl)benzene [ACD/IUPAC Name]
4-Chloro-2-nitro-1-(phénylsulfonyl)benzène [French] [ACD/IUPAC Name]
4-Chloro-2-nitrophenyl phenyl sulfone
86030-08-2 [RN]
Benzene, 4-chloro-2-nitro-1-(phenylsulfonyl)- [ACD/Index Name]
BTB-1
[86030-08-2] [RN]
1-(2,4-dichlorophenyl)-1-cyclopropanecarboxylic acid
1-(benzenesulfonyl)-4-chloro-2-nitrobenzene
1-Benzenesulfonyl-4-chloro-2-nitrobenzene
1-Benzenesulfonyl-4-chloro-2-nitro-benzene
2-Benzenesulfonyl-5-chloronitrobenzene
4-chloro-2-nitro-1-(phenylsulfonyl)-benzene
4-Chloro-2-nitro-1-(phenylsulphonyl)benzene
4-Chloro-2-nitrodiphenyl sulfone
4-Chloro-2-nitrodiphenyl sulfone; 1-(Benzenesulfonyl)-4-chloro-2-nitrobenzene
4-Chloro-2-nitrodiphenyl sulphone
4-Chloro-2-nitrodiphenylsulfone
87395-64-0 [RN]
BTB 1
BTB1
MFCD00052250 [MDL number]
N-(1-Hydroxy-2-(hydroxymethyl)-4-(4-octylphenyl)butan-2-yl)acetamide
NSC 156750; NSC 658180
SS-5790

SMILES

c1ccc(cc1)S(=O)(=O)c2ccc(cc2[N+](=O)[O-])Cl

StdInChI

InChI=1S/C12H8ClNO4S/c13-9-6-7-12(11(8-9)14(15)16)19(17,18)10-4-2-1-3-5-10/h1-8H

StdInChIKey

VZDUQPHKUBZMLW-UHFFFAOYSA-N

Molecular Formula

C12H8ClNO4S

Molecular Weight

297.714

Properties

Appearance

White to off-white

Structure

Structure of BTB-1 CAS 86030-08-2
Structure of BTB-1 CAS 86030-08-2

Safety Data

Symbol

Signal Word

Warning

WGK Germany

3

MSDS Download

Specifications and Other Information of Our

Identification Methods

HNMR, HPLC

Water

Loss on Drying

Residue on Ignition

Single Impurity

Total Impurities

Shelf Life

2 years

Storage

store at room temperature away from light; Sealed in dry.

Known Application

BTB1 also called 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE, is a selective and ATP-competitive mitotic kinesin Kif18A inhibitor (IC50 = 1.7 μM); reversibly inhibits microtubule-stimulated Kif18A ATPase activity. BTB1 shows cell toxicity with an EC50 values of 35.8μM. HeLa cells treated with 50μM BTB1 reveals severe defects inspindle morphology and chromosome alignment.Treatment with high concentrations of BTB-1 does not result in elongated spindles.

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